<img src="https://ml.globenewswire.com/Resource/Download/8d978f50-07a9-40a3-be69-45f51ccd94d9?size=2" nborder="0" align="left" hspace="5" vspace="5" title="Akari Logo (1).jpg" alt="Akari Therapeutics Plc"/>Discussion highlights Vat-Ho’s oncology business development experience, his decision to join Akari and the potential of the Company’s novel PH1 payload platform Watch the “What This Means” video <a href="https://www.globenewswire.com/Tracker?data=f8VL3j5PYA6ImpIYD9O7sEIyP24CPbuWqP4DneVkap4QNgOUrLvYudk6W5bnsKEEgSQJEmax5ZTggHywWTVHhl4GxUw9vcDkitOmJsqAE-Q=" rel="nofollow" target="_blank" title="">here</a> TAMPA, Fla. and LONDON, Nov. 11, 2026 <a href="https://www.globenewswire.com" target="_blank">(GLOBE NEWSWIRE)</a> -- Akari Therapeutics, Plc (Nasdaq: AKTX), an oncology biotechnology company developing antibody drug conjugates (ADCs) with a novel RNA splicing disrupting payload, today announced its participation in a Virtual Investor “What This Means” segment featuring Vatnak Vat-Ho, the Company’s newly appointed Chief Business Officer. During the segment, Mr. Vat-Ho discusses his background in oncology business development and strategic partnering, including experience with novel ADC payload technologies, and what attracted him to Akari. He highlights the potential of the Company’s PH1 payload, its differentiated dual mechanism of action and opportunities to advance its application across multiple ADC constructs. Mr. Vat-Ho also shares his perspective on joining Akari as its lead candidate, AKTX-101, progresses toward clinical development. The discussion explores his priorities as Chief Business Officer, including advancing strategic collaborations, supporting investor engagement and translating the Company’s scientific progress into long-term value. The segment concludes with Mr. Vat-Ho’s perspective on the evolving ADC landscape and the role of payload innovation in shaping the next generation of cancer therapies. The Virtual Investor "What This Means" segment featuring Akari Therapeutics is now available <a href="https://www.globenewswire.com/Tracker?data=f8VL3j5PYA6ImpIYD9O7sFnYVRuseJ0wG-ZrhgfT4iDp-LqxO3awHjz-kVy1fJZHbs1zdSvqmpeHf4sfUjwgkLQpHI36uTvFjg_EGbYE8Ek=" rel="nofollow" target="_blank" title="here">here</a>. About Akari Therapeutics Akari Therapeutics is an oncology biotechnology company developing next-generation antibody drug conjugates (ADCs) with a unique payload, PH1, which targets RNA splicing. Utilizing its innovative ADC discovery platform, the Company has the ability to generate ADC candidates and optimize them based on the desired application to any antigen target of interest. Akari’s lead candidate, AKTX-101, targets the Trop2 receptor on cancer cells with a proprietary linker, enabling it to deliver its novel PH1 payload directly into the tumor with minimal off-target effects. Unlike current ADCs that use microtubule inhibitors and DNA-damaging agents as their payloads, PH1 is a novel payload that is a spliceosome modulator designed to disrupt RNA splicing within cancer cells. This splicing modulation has been shown in preclinical animal models to induce cancer cell death while activating both the innate and adaptive immune systems to drive robust and durable activity. In preclinical studies, AKTX-101 has been shown to have significant activity and prolonged survival relative to ADCs with traditional payloads. Additionally, AKTX-101 has the potential to be synergistic with checkpoint inhibitors and has demonstrated prolonged survival as both a single agent and in combination with checkpoint inhibitors. The PH1 payload has also been demonstrated to be very active against cancer cells with key oncogenic drivers such as KRAS, BRAF, AR-V7, FGFR3 fusions, and others. The Company has initiated IND enabling studies for AKTX-101 with a goal of starting its First-In-Human trial by mid-2027. Akari is also developing AKTX-102, an ADC candidate targeting CEACAM5 (Carcinoembryonic Antigen-related Cell Adhesion Molecule-5), a well-validated tumor antigen broadly expressed across multiple solid tumors. AKTX-102 is designed to leverage Akari’s proprietary PH1 spliceosome-modulating payload and a novel antibody construct to enable differentiated tumor cell killing and immune activation. For more information about the Company, please visit <a href="https://www.globenewswire.com/Tracker?data=96UKFO_sjvZOU5LAy6s8naRCiLb4Nu7I9BJPgVT2qbhs_gGQ-fE2WOmdAOyZpSu5AnhjvfBSubfcsE0fmKcbcL58l-via7xzg5Z3W8lDbxM=" rel="nofollow" target="_blank" title="www.akaritx.com">www.akaritx.com</a> and connect on <a href="https://www.globenewswire.com/Tracker?data=G9N46wEF39YUoyDOE0t-ZlDMh-eEtinTJCAzIvI6YsguDpHggZqzP38lG0olq3ZQWfDLOgRGWi_fW5IY5CCVuw==" rel="nofollow" target="_blank" title="X">X</a> and <a href="https://www.globenewswire.com/Tracker?data=MLZdMI334m_eMVY3mz4j_U6F82go2hhvDqaztR4Ndp-ADwsWOxHGv6v74knvYoV1ZgDaK_wCrQGSfl2kdCQguoi2AGgj83_GoXoMW3zBlJs=" rel="nofollow" target="_blank" title="LinkedIn">LinkedIn</a>. Cautionary Note Regarding Forward-Looking Statements This press release includes express or implied forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, about the Company that involve risks and uncertainties relating to future events and the future performance of the Company. Actual events or results may differ materially from these forward-looking statements. Words such as “will,” “could,” “would,” “should,” “expect,” “plan,” “anticipate,” “intend,” “believe,” “estimate,” “predict,” “project,” “potential,” “continue,” “future,” “opportunity” “will likely result,” “target,” variations of such words, and similar expressions or negatives of these words are intended to identify such forward-looking statements, although not all forward-looking statements contain these identifying words. Examples of such forward-looking statements include, but are not limited to, express or implied statements regarding the potential characteristics and therapeutic applications of PH1 and PH1-based ADCs, the ability of the Company to advance its product candidates for the treatment of cancer and the timing of a filing of an IND and commencement of a Phase I clinical trial. These statements are based on the Company’s current plans, estimates and projections. By their very nature, forward-looking statements involve inherent risks and uncertainties, both general and specific. A number of important factors, including those described in this communication, could cause actual results to differ materially from those contemplated in any forward-looking statements. Factors that may affect future results and may cause these forward-looking statements to be inaccurate include, without limitation: the Company’s need for additional capital; the potential impact of unforeseen liabilities, future capital expenditures, revenues, costs, expenses, earnings, synergies, economic performance, indebtedness, financial condition and losses on the future prospects, business and management strategies for the management, expansion and growth of the business; risks related to global as well as local political and economic conditions, including interest rate and currency exchange rate fluctuations; potential delays or failures related to research and/or development of the Company’s programs or product candidates; risks related to any loss of the Company’s patents or other intellectual property rights; any interruptions of the supply chain for raw materials or manufacturing for the Company’s product candidates, including as a result of potential tariffs; the nature, timing, cost and possible success and therapeutic applications of product candidates being developed by the Company and/or its collaborators or licensees; the extent to which the results from the research and development programs conducted by the Company, and/or its collaborators or licensees may be replicated in other studies and/or lead to advancement of product candidates to clinical trials, therapeutic applications, or regulatory approval; uncertainty of the utilization, market acceptance, and commercial success of the Company’s product candidates; risks related to competition for the Company’s product candidates; and the Company’s ability to successfully develop or commercialize its product candidates. While the foregoing list of factors presented here is considered representative, no list should be considered to be a complete statement of all potential risks and uncertainties. More detailed information about the Company and the risk factors that may affect the realization of forward-looking statements is set forth in the Company’s filings with the SEC, copies of which may be obtained from the SEC’s website at www.sec.gov. The Company assumes no, and hereby disclaims any, obligation to update the forward-looking statements contained in this press release except as required by law. Investor Relations Contact JTC Team, LLC Jenene Thomas 908-824-0775 <a href="https://www.globenewswire.com/Tracker?data=NgKcM9T6rf9s_r-fFGYKfCbzT6jTu90AKNyu1ZiDeojN0Zb9KZc5RXdi7alNVx2Fvjbo7HwLMR_dq9Aln8uiCw==" rel="nofollow" target="_blank" title="AKTX@jtcir.com">AKTX@jtcir.com</a> <img alt="" src='https://ml.globenewswire.com/media/Y2I0NzNmZmEtNzk3NS00MGQzLWE1MWEtNjRlMDBlZjJjZDJkLTEwMzE4MzUtMjAyNi0xMS0xMS1lbg==/tiny/Akari-Therapeutics-Plc.png' referrerpolicy='no-referrer-when-downgrade' />

Akari Therapeutics Participates in Virtual Investor “What This Means” Segment Featuring Newly Appointed Chief Business Officer Vatnak Vat-Ho

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