<img src="https://ml.globenewswire.com/Resource/Download/2b8cbfab-a4de-4e17-bdd6-7ef597a95d2e?size=2" nborder="0" align="left" hspace="5" vspace="5" title="Cogent_Biosciences_logo_RGB.png" alt="Cogent Biosciences, Inc."/><ul type="disc"><li style="list-style-position:inside; text-align:center;">Pivotal data from APEX trial in Advanced Systemic Mastocytosis accepted for oral presentation; Cogent’s third oral presentation of pivotal data with bezuclastinib at major medical meetings  </li><li style="list-style-position:inside; text-align:center;">Preclinical data from selective, potent JAK2 V617F program accepted for poster presentation</li></ul> WALTHAM, Mass. and BOULDER, Colo., May 12, 2026 (GLOBE NEWSWIRE) -- <a href="https://www.globenewswire.com/Tracker?data=9c8B-dBTVI2rjZyWl71nBhi09fg1IJgE0vwg_VwJ-3sPofZTh0P0UNHylbk6RcbmQwPmVpxFFjtUqMifijMcCy-sIM6enHtp8IfE_ai7feZm1B74tbXX6xPvMsBoBRi4GEQ5XtyPy8zkDZ_VWk38hm3sMHfhJTIE5O5OHmsTjmmJxBVmLLthGa4bVjeEeR1gF8EUj5jZ0xWNd9RUvONstgHPyNtiZBFuFSpTMC6E7btkRAwS9_rLp1VhkGFmBlMUNHMVkHRmReONi0nai5cIZw==" rel="nofollow" target="_blank" title="Cogent Biosciences, Inc.">Cogent Biosciences, Inc.</a> (Nasdaq: COGT), a biotechnology company focused on developing precision therapies for genetically defined diseases, today announced two presentations from the company’s Advanced Systemic Mastocytosis (AdvSM) program, including an oral presentation highlighting the results of the APEX trial, as well as a poster presentation from its emerging JAK2 V617F program at the European Hematology Association (EHA) Congress being held in Stockholm, Sweden, June 11-14, 2026. Details of the presentations are as follows: Bezuclastinib  Oral Presentation Abstract Title: Efficacy and Safety of Bezuclastinib in Patients With Advanced Systemic Mastocytosis: Primary Results From the Apex Study Presenter: Daniel DeAngelo, M.D., Ph.D., Chief of the Division of Leukemia at the Dana-Farber Cancer Institute and Professor of Medicine, Harvard Medical School Session Date and Time: June 13, 2026 – 17:15 – 18:30 CEST (11:15 AM ET – 12:30 PM ET) Oral Session: S438 Myeloproliferative Neoplasms – Clinical Session Room: A2-3 Hall Poster Presentation Abstract Title: The Effect of Bezuclastinib on the Pathobiology of Advanced Systemic Mastocytosis: Results from the Pivotal Apex Trial Poster #: PF885 Presenter: Tracy George, M.D., President and Chief Scientific Officer at ARUP Laboratories, Professor of Pathology at the University of Utah School of Medicine   Session Date and Time: June 12, 2026 – 18:45-19:45 CEST (12:45pm - 1:45pm ET) JAK2 V617F Poster Presentation Abstract Title: Preclinical characterization of CGT1145 a novel, wild-type-sparing, JAK2 V617F mutant-selective inhibitor Poster #: PF853 Presenter: Mark J Chicarelli, Senior Director Medicinal Chemistry, Cogent Biosciences Session Date and Time: June 12, 2026 – 18:45-19:45 CEST (12:45pm - 1:45pm ET) About Cogent Biosciences, Inc. Cogent Biosciences is a biotechnology company focused on developing precision therapies for genetically defined diseases. The most advanced clinical program, bezuclastinib, is a selective tyrosine kinase inhibitor that is designed to potently inhibit the KIT D816V mutation as well as other mutations in KIT exon 17. KIT D816V is responsible for driving systemic mastocytosis, a serious disease caused by unchecked proliferation of mast cells. Exon 17 mutations are also found in patients with advanced gastrointestinal stromal tumors (GIST), a type of cancer with strong dependence on oncogenic KIT signaling. In addition, the Cogent Research Team is developing a portfolio of novel targeted therapies to help patients fighting serious, genetically driven diseases targeting mutations in ErbB2, PI3Kα, KRAS and JAK2. Cogent Biosciences is based in Waltham, MA and Boulder, CO. Visit our website for more information at www.cogentbio.com. 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Cogent Biosciences Announces Multiple Presentations at the European Hematology Association (EHA) 2026 Congress

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