<img src="https://ml-eu.globenewswire.com/Resource/Download/4e957060-eef5-4c1b-81e6-73683a4daa1e?size=2" nborder="0" align="left" hspace="5" vspace="5" title="INVENTIVA" alt="INVENTIVA"/><ul type="disc"><li style="margin-top:6pt; margin-bottom:6pt; text-align:justify;">Cash and cash equivalents at €75.0 million, and €121.5 million in short-term deposits2 </li></ul> Daix (France), New York City (New York, United States), May 26, 2026 – <a href="https://www.globenewswire.com/Tracker?data=WUiRvO90VumP8yW7olmung8x9T_ggGBdwUI-pRZeee1WYOsH3rti_ju7maM9dzZiMyzhk_xC4314H5IrsRpSJMHmNE8e5bx1usOtKzADMS8=" rel="nofollow" target="_blank" title="Inventiva">Inventiva</a> (Euronext Paris and NASDAQ: <a href="https://www.globenewswire.com/Tracker?data=Ad1jHwTFkV09D8nvacvrt5YXJQkw0v0la87k9X-sHWnQ7c5GjjmAuLUld4zP3nC5Etd2uq1Bs7B_TsbU9mDlr41hYbiIDO6OXYe5rL8eY5ZOS4dOe5fwI9__mQrYEANl" rel="nofollow" target="_blank" title="IVA">IVA</a>) (“Inventiva” or the “Company”), a clinical-stage biopharmaceutical company focused on the development of oral therapies for the treatment of metabolic dysfunction-associated steatohepatitis (“MASH”), today reported its financial information for the first quarter of 2026, including its cash, cash equivalents and revenues. Key Financial Results Cash, Cash Equivalents and Deposits As of March 31, 2026, the Company's cash and cash equivalents amounted to €75.0 million and its short-term deposits2 to €121.5 million, compared to cash and cash equivalents of €99.3 million and short-term deposits of €131.6 million as of December 31, 2025. The net cash used was mainly the result of the Company’s planned operating activities related to its lanifibranor development program. Considering its current cost structure and projected expenses, the Company estimates that its cash, cash equivalents, and short-term deposits should enable it to finance its operations until the middle of the first quarter of 20273. If the Tranche 3 warrants issued in the structured financing announced by the Company in October 2024 (the “Structured Financing”) are exercised in full for proceeds of up to €116.0 million, the Company estimates that such potential additional proceeds would enable it to finance its activities until the middle of the third quarter of 20273. There is no guarantee that the Tranche 3 warrants will be exercised in full, if at all. Revenues The Company did not recognize revenues for the first quarter of 2026, in line with the first quarter of 2025. Anticipated Potential Key Milestones <ul type="disc"><li style="text-align:justify;">Topline results of NATiV3 – expected in the fourth quarter of 2026 </li></ul> Upcoming Conference Participation <ul type="disc"><li style="text-align:justify;">EASL Congress, Barcelona, May 27-30</li><li style="text-align:justify;">2026 Jefferies Global Healthcare Conference, New York, June 2-4, 2026</li><li style="text-align:justify;">Portzamparc BNP Paribas group mid &amp; small caps conference 2026, Paris, June 25, 2026 </li></ul> Next Financial Results Publication <ul type="disc"><li style="text-align:justify;">Revenues and cash and cash equivalents for the first half of 2026: Wednesday, July 29, 2026 (after U.S. market close) </li></ul> About Inventiva Inventiva is a clinical-stage biopharmaceutical company focused on the research and development of an orally administered small molecule for the treatment of patients with MASH. The Company is currently evaluating lanifibranor, a novel pan-PPAR agonist, in the NATiV3 pivotal Phase 3 clinical trial for the treatment of adult patients with MASH, a common and progressive chronic liver disease. Inventiva is a public company listed on compartment B of the regulated market of Euronext Paris (ticker: IVA, ISIN: FR0013233012) and on the Nasdaq Global Market in the United States (ticker: IVA). <a href="https://www.globenewswire.com/Tracker?data=0eiIiypa0HZxBicUUZYcpzLSYPNgcGbaX_SeW99DaDDGcq4O5TKQd84YRs1mkUWOvbf94EvYfpeNyQwm8bJS4UAev6IsAgVhUR5Bd-Xp_heRoWdjLNmktd_Z8TU0bwn3" rel="nofollow" target="_blank" title="">https://www.inventivapharma.com</a> Contacts <table style="border-collapse: collapse; width:471pt; border-collapse:collapse ;"><tr><td style="width:314px;;text-align: justify ; vertical-align: middle; vertical-align: top ; text-align: justify ; vertical-align: middle; ">Media Relations Pascaline Clerc: <a href="mailto:media@inventivapharma.com" rel="nofollow" target="_blank" title="media@inventivapharma.com">media@inventivapharma.com</a> Mark Corbae: <a href="mailto:inventivapr@icrhealthcare.com" rel="nofollow" target="_blank" title="inventivapr@icrhealthcare.com">inventivapr@icrhealthcare.com</a>  </td><td style="width:314px;;text-align: justify ; vertical-align: middle; vertical-align: top ; text-align: justify ; vertical-align: middle; ">Investor Relations David Nikodem: <a href="mailto:IR@inventivapharma.com" rel="nofollow" target="_blank" title="IR@inventivapharma.com">IR@inventivapharma.com</a> Patricia L. Bank: <a href="mailto:patti.bank@icrhealthcare.com" rel="nofollow" target="_blank" title="patti.bank@icrhealthcare.com">patti.bank@icrhealthcare.com</a>  </td></tr></table> Forward-Looking Statements This press release contains “forward-looking statements” within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical fact, included in this press release are forward-looking statements. These statements include, but are not limited to, unaudited financial results for Inventiva’s three months ended March 31, 2026, forecasts and estimates regarding Inventiva's cash resources and expenses, including expectations with respect to EIB mattersand assumptions in connection with Inventiva’s estimated cash runway, the potential exercise by investors of warrants and pre-funded warrants, including warrants and pre-funded warrants issued in connection with the Structured Financing, potential milestone and royalty payments the Company may receive under its agreement with Biossil with respect to odiparcil, including the timing thereof, forecasts and estimates with respect to Inventiva’s NATiV3 Phase 3 clinical trial with lanifibranor in patients with MASH, including the quality of trial results, design, duration, timing, costs, and funding,timing of clinical trial data releases and publications, the information, insights and impacts that may be gathered from clinical trials, the potential therapeutic benefits of lanifibranor, potential regulatory submissions, approvals and commercialization, Inventiva’s pipeline and development plans, and Inventiva's future activities, expectations, plans, growth and prospects. Some of these statements, forecasts, and estimates may be identified by the use of words such as, without limitation, “believe,” “anticipate,” “expect,” “intend,” “plan,” “seek,” “estimate,” “may,” “will,” “could,” “should,” “designed,” “hope,” “target,” “potential,” “opportunity,” “possible,” “aim,” and “continue” and other similar expressions. These statements are not historical facts, but rather statements of future expectations and other forward-looking statements based on management's beliefs. These statements reflect the opinions and assumptions prevailing as of the date of the statements and involve known and unknown risks and uncertainties that could cause future results, performance, or events to differ materially from those expressed or implied in such statements. Actual events are difficult to predict and may depend on factors beyond Inventiva's control. There can be no guarantee, with respect to product candidates, that clinical trial results will be available on schedule, that future clinical trials will be initiated as planned, that product candidates will receive the necessary regulatory approvals, or that the milestones planned by Inventiva or its partners will be achieved on schedule, or even at all. Future results may differ materially from the anticipated future results, performance, or achievements expressed or implied by these statements, forecasts, and estimates due to a number of factors, including the fact that interim data or data from any interim analysis of ongoing clinical trials do not predict the future results of clinical trials, the fact that the DMC's recommendation does not prejudge any eventual marketing authorization, that Inventiva cannot provide assurance on the impacts of the Suspected Unexpected Serious Adverse Reaction (SUSAR) on recruitment or the final impact on the results or timing of the NATiV3 trial or related regulatory issues, Inventiva is a clinical-stage company with no approved products and no historical revenue, Inventiva has incurred significant losses since its inception, Inventiva has never generated revenue from product sales, Inventiva will need additional capital to fund its operations, without which Inventiva may be required to significantly reduce its activities, delay or discontinue one or more of its research or development programs, expand its activities or capitalize on its business opportunities, and may not be able to continue as a going concern. Inventiva's ability to obtain financing and complete potential transactions on a timely basis, as well as whether, when, and to what extent dilutive instruments may be exercised and by which holders, Inventiva's future success depends on the successful clinical development, regulatory approvals, and subsequent commercialization of lanifibranor, preclinical studies or previous clinical trials are not necessarily predictive of future results, and the results of Inventiva's and its partners' clinical trials may not support Inventiva's and its partners' claims regarding product candidates, Inventiva's expectations regarding its clinical trials may prove to be incorrect, and regulatory authorities may require additional stops and/or modifications to Inventiva's clinical trials. Inventiva's expectations regarding the clinical development plan for lanifibranor for the treatment of MASH may not be realized and may not support the approval of a New Drug Application, Inventiva's ability to implement its commercialization, marketing, and manufacturing capabilities and strategy, Inventiva's ability to successfully cooperate with its existing partners or enter into new partnerships, and to fulfil its obligations under any agreements entered into in connection with such partnerships, the benefits of its current and future partnerships on the clinical development, regulatory approvals, and, if applicable, commercialization of its product candidates, as well as the achievement of milestones and timelines anticipated in connection with such partnerships, Inventiva and its partners may encounter substantial delays beyond expectations in their clinical trials or fail to demonstrate safety and efficacy to the satisfaction of the applicable regulatory authorities, the ability of Inventiva and its partners to recruit and retain patients in clinical studies, the recruitment and retention of patients in clinical trials is a costly and time-consuming process that could be made more difficult or impossible by multiple factors beyond the control of Inventiva and its partners, Inventiva's product candidates may cause adverse reactions or have other properties that could delay or prevent their regulatory approval, or limit their commercial potential, Inventiva faces significant competition, and Inventiva's activities, preclinical studies, and clinical development programs, as well as timelines, Inventiva's financial condition and results of operations could be materially and adversely affected by changes in laws and regulations, adverse conditions in its industry, geopolitical events, such as the conflict between Russia and Ukraine and the resulting sanctions, the conflict in the Middle East and the related risk of a wider conflict and ongoing conflicts, epidemics, and macroeconomic conditions, including changes in international trade policies, global inflation, fluctuations in financial and credit markets, customs duties and other trade barriers, political unrest and natural disasters, uncertain financial markets, and disruptions in banking systems. In light of these risks and uncertainties, no representation is made as to the accuracy or completeness of these forward-looking statements, forecasts, and estimates. Furthermore, forward-looking statements, forecasts, and estimates are only valid as of the date of this press release. Readers are cautioned not to place undue reliance on these forward-looking statements. Please refer to the Universal Registration Document for the fiscal year ended December 31, 20242025, filed with the Autorité des Marchés Financiers on April 158, 2025, the semi-annual financial report as of June 30, 2025, published on September 29, 20252026, and the Annual Report on Form 20-F for the fiscal year ended December 31, 20242025 filed with the Securities and Exchange Commission (the “SEC”) on April 15, 2025 and the Half-Year Report for the six months ended June 30, 2025 on Form 6-K filed with the SEC on October 15, 20258, 2026 for other risks and uncertainties affecting Inventiva, including those described under the heading “Risk Factors,” and in future filings with the SEC. Other risks and uncertainties that Inventiva is not currently aware of may also affect its forward-looking statements and may cause actual results and timing of events to differ materially from those anticipated. All information contained in this press release is current as of the date of this release. Except as required by law, Inventiva has no intention or obligation to update or revise the forward-looking statements mentioned above. Therefore, Inventiva accepts no responsibility for the consequences arising from the use of any of the above statements. <hr /> <ol style="list-style-type:decimal;"><li style="text-align:justify;">Non-audited financial information.</li><li style="text-align:justify;">Short-term deposits were classified as “other current assets” in the consolidated statement of financial position in accordance with IFRS and were considered by the Company to be liquid and readily available.</li><li style="text-align:justify;">This estimate is based on the Company's current business plan, but excludes potential milestone payments to be paid or received by the Company, any potential proceeds from the exercise of Tranche 3 warrants issued as part of the Structured Financing (unless specifically stated), as well as any additional expenses related to other product candidates or resulting from the licensing or acquisition of additional product candidates or technologies, or any related developments that the Company may pursue. The Company may have based these estimates on assumptions that are incorrect or may amend its business plan in the future, and the Company may end up using its resources sooner than anticipated. These estimates may be shortened in the event of an increase, beyond the Company's expectations, in expenditure relating to the development program, or if the development program of the Company progresses more quickly than expected.</li></ol> 
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Inventiva Reports 2026 First Quarter Financial Information¹

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