<img src="https://ml.globenewswire.com/Resource/Download/6a9e3f3f-d4fb-4bf0-9480-3bbd3fd2ced9?size=2" nborder="0" align="left" hspace="5" vspace="5" title="Pliant_logo_300x300.jpg" alt="Pliant Therapeutics, Inc."/>Highlights FORTIFY, the Phase 1b indication expansion trial of PLN-101095  enrolling patients with ICI-refractory solid tumors SOUTH SAN FRANCISCO, Calif., May 21, 2026 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (Nasdaq: PLRX) today announced a presentation at the upcoming 2026 American Society of Clinical Oncology (ASCO) Annual Meeting taking place in Chicago, Illinois from May 29 to June 2, 2026. Poster Presentation Title: <a href="https://www.globenewswire.com/Tracker?data=7n4Ka6859iALwU6Mw1jh49LI_APJ74da7mXg_CS3hUOV1mdACR6SbwDHsc4e5rFvLDCFs2gDyErHwUBxV5nhSc5ryvTj1Cxvnig1auGiicMH1agZz8k_uOpv2FLebMdzPBNcuaciYoZp8W690Q_po0UftwoPpT89V0gbtF10FSpoTo_Z5odFEHukfNyB-nd3GPUWpMQQfO1n6e91K0rkHFUi0JV_UeO_JiowAsWNDEb7L5R8rV1qCv-UrnPcnFoh-6c0hmhN8wxLeyBgRBhwtgjnuiRuQWryz0OF8ZYerTQGjrqLkgaSJeVatqyj9mzMRkmxDLr38fWlm4w2ih_0uVISsfjm88Ic1PGuCodrX4hXRnk55hUelk25g8LyUgT9aWNh1JbAaseKnHdtxszxew==" rel="nofollow" target="_blank" title="Cohort Expansion of a Phase I Study of PLN-101095, a First-in-Class Dual αvβ8 /αvβ1 Integrin Inhibitor, in Combination with Pembrolizumab in Patients with Advanced Solid Tumors Refractory to Immune Checkpoint Inhibitors">Cohort Expansion of a Phase I Study of PLN-101095, a First-in-Class Dual αvβ8 /αvβ1 Integrin Inhibitor, in Combination with Pembrolizumab in Patients with Advanced Solid Tumors Refractory to Immune Checkpoint Inhibitors</a> <table style="border-collapse: collapse; width:100%; border-collapse:collapse ;"><tr><td style="max-width:10%; width:10%; min-width:10%;">Presenter:</td><td style="max-width:90%; width:90%; min-width:90%;">Timothy A. Yap, MBBS, Ph.D., University of Texas, M.D. Anderson Cancer Center</td></tr><tr><td>Session:</td><td>Developmental Therapeutics – Immunotherapy</td></tr><tr><td>Date:</td><td>Saturday, May 30, 2026, 1:30 – 4:30 p.m. Central Time</td></tr><tr><td>Location:</td><td>Hall A, Poster 467b</td></tr></table> FORTIFY - PLN-101095 Phase 1b Indication Expansion Trial PLN-101095 is currently being evaluated in Phase 1a/1b open-label, dose-escalation and indication expansion trial (<a href="https://www.globenewswire.com/Tracker?data=2nUMTeJU2uS1BK1K4leA3IIrjXaJ0e43MB-UEO-1exdKCChpcsxa4x0tKI_jNwGBN8U0xdv1SH7-6iY48VBiynfpQggI8kyUNcjQhx-SBSt3oua-Am_Tpg9rrPJ9H2T_" rel="nofollow" target="_blank" title="NCT06270706">NCT06270706</a>) to evaluate the safety, tolerability, pharmacokinetics, and preliminary evidence of antitumor activity of PLN-101095 when administered orally in combination with pembrolizumab, in patients with immune checkpoint inhibitor (ICI)-refractory advanced or metastatic solid tumors. Pliant is currently enrolling patients in FORTIFY, a Phase 1b open-label, indication expansion trial enrolling three cohorts of patients with non-small cell lung cancer (NSCLC), tumors with high tumor mutational burden or clear cell renal cell carcinoma. Patients will be treated for 14 days with PLN-101095 dosed at 1,000 mg twice daily as monotherapy, after which pembrolizumab will be added as combination therapy. About Pliant Therapeutics, Inc. Pliant Therapeutics is a clinical-stage biopharmaceutical company focused on the discovery and development of integrin-based therapeutics. Pliant’s lead program is PLN-101095, an oral, small molecule, dual-selective inhibitor of αvß8 and αvß1 integrins, that is being developed for the treatment of ICI-refractory advanced or metastatic solid tumors. PLN-101095 is being investigated in FORTIFY, a Phase 1b indication expansion trial enrolling patients with NSCLC, tumors with high tumor mutational burden or clear cell renal cell carcinoma. Pliant’s preclinical research is focused on tissue-specific delivery and internalization of drug payloads utilizing integrin receptor-binding molecules with programs focused on delivering siRNAs to skeletal muscle cells, adipocytes, and renal cells. For additional information on Pliant, visit <a href="https://www.globenewswire.com/Tracker?data=0LHPNldMeH5CExV_hTUuKRbjOZoRoc9ByUDEdPsuhsHd8JhLgjdL6TXP2008fVuMryZiGBEcKOx5BIBwnkVhuZZCmZXOwWttgkbuJp-dp8epWYemtWQbFAcv1ySQU8l7k7-tY8ROKdEnFAjppIQMh_EX2haYR7QLio_FSL8QisEOuZDXXKJhmDN7Kdp9t44mVNn6yq3MmDbQ6rJ0SMhTigBWLHwewslvus7ycXnrNMclCOKhB6f6hDXUBUyLNt9xJghx0GCsN_2HT_sRy_yX5Ikai-lAy-4-eO5VYOc__bwBHkeKO1nKssLNazYmZMee5K12ve-ZXOjylj4If5jlD5UvFIufkUxkfVynovwE_EgCdPnAcQkFJj-lQlGvJ566KTBrpoJqWw1jG8Ndh5U4ZO2n_mVVnn9fmjv9hW4jtHxCJqPoYE9GnphgD6vRWC3oyFfTtDvUA7T0OePYqvFN5FDtykkOzI2zeKOg2rIYVxI=" rel="nofollow" target="_blank" title="www.PliantRx.com">www.PliantRx.com</a> and follow us on <a href="https://www.globenewswire.com/Tracker?data=oConL-4-Gx7eY7vJ2cwJHxS3CI5LhzORULLIlR-8pfdMzZ-79Nlayf6DWKeRgo9OjpMg1OVxBWcjoUsD-KzVVnYd3HL_-JPZ0S1C1K2r1_3ixDVyJTAW3rFUfi2hnioABsqCwNbmSUO8jNszdtqiL-qMZUpiw4VYNNHCR57xu2zVipfL8ZQA-IGELPFLgw6VQdSHsjOpWKMKJFIdgOHjJ7MJ_KKUEcFO3BVTN7QiXxNArsiZ5FytXqdxdpkPgFgdDEumqaFbVt4u8us83FgubIhz_RMz5yqdjJVa0dxsSfxFNHH0iW1ep9LUdt2-uK2UQcpMcDRO63hf7ptT5gRjAdW55jpgUYgCE_4Fw1rw3IH0-FzSjMamv13QtmjCJmGX" rel="nofollow" target="_blank" title="X">X</a>, <a href="https://www.globenewswire.com/Tracker?data=C5Q5ig1tfzFdCkrewSnVvdxqGv-LXJ0oT2y_2E3Gb-1VOMNOr6MbXp0dhdxqD7Dz6Rsu0qac3eXLpsFC3ZxU1phcd_9GM4sXOdngcF6O76GaHKzPiIP6UvjPIddvqo4LgNrsXd707w7c8tYWDjVlyLWLomMkkS72P2r_rk73GP3dcv-rQ2wBbNVoT9bGs-CZNsLkkJ4cUn9NKsnCIDtPj46EiR8F8lmHpFNHaizFipCy0Vbd5Qd1fZ2E0TmBftTts4lIeK7eUYh5YAPBF9AShVLs4cdG50e2aJLFFYWxZmzO_xqjLVGZz6iEOQdtl5ItDNWPrVNbmPGuhSzv6fm4TRURIG7GFde75RkniqjAhU3-p_V8tpLKrd44WHGb_quGc1M7JlCTrlsebmR0tr1pQsUYAAb5oOeMloefViNAH-hZHU73Kq59A2AGSfx-VkYw" rel="nofollow" target="_blank" title="LinkedIn">LinkedIn</a> and <a href="https://www.globenewswire.com/Tracker?data=Ceahoi3NwdXJDN2aBBWjKOjifviEM5A-Y-ASJBsT7BhAUo0gp55VcJhTN1eIz3EVJZjovQ5hnlZ9tO-qu0Lm_2n0kAMi1jxhiSG48Upws77wMbj1kB29H6N7oMX7aFZxP--7FJzF4zeVkK9Pt62X892styhCgEvgGfKbvsElliYqJNdv27K_ktwYbSYsExTgITQG5xSpqz5hVwmM2Usb_gr4SApWlw1VOLNT8moMx3TvPEWn2h3nze--c7AORWXR7dVO2RfhNa3DJ1ADx1kkFPWflNw0JzxaSconfBjSPeuNGMc1_n3BUtD_vFz8-sTHfkmK7_g761pkvmC2IcT80x0gvalFGvZi0VaiBgP_kBkWQE9-rePOjV24q-m7qxeNwFBRCk51hD7fmqMronN2tCs8ZD_M8KvUEgbUdNtiTJ6loI9BDyrYoOWhtgUezMGU" rel="nofollow" target="_blank" title="Facebook">Facebook</a>. Investor and Media Contact: Christopher Keenan Vice President, Investor Relations and Corporate Communications Pliant Therapeutics, Inc. <a href="https://www.globenewswire.com/Tracker?data=eJmiX59t0LL-y3z0yCUR2dXnAsVSLIbQ40hwKE2OCwfSLf_b4RTxesazBCT4Mrfxw-lq4j9QyeQDe61aDpTZip4jZTf8z3RadrrexlqONsecDbKufcQm_sJEUnqKH7bDuCx_HC5ciwb6Vw_u6Rc4tQtjdhai2iby4SwhoGNpEgdC6ueNWfWnnC4VxyLcPDALfZFBLhVPUv88HUs58bwShTG35gYMox0bslDmBk1RiN1-UXwVAXrOOlWlULSlMsw2j2Ha4H60GdytGuh2pXdBhA==" rel="nofollow" target="_blank" title="ir@pliantrx.com">ir@pliantrx.com</a> <img alt="" src='https://ml.globenewswire.com/media/NmQ5ODZmYjAtNDcxMi00ZTIyLWFiYmEtNzFiOTU5ODBhNTcxLTExOTcwMzAtMjAyNi0wNS0yMS1lbg==/tiny/Pliant-Therapeutics-Inc-.png' referrerpolicy='no-referrer-when-downgrade' />

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Pliant Therapeutics Announces Upcoming Presentation at the 2026 American Society of Clinical Oncology Annual Meeting

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