<img src="https://ml.globenewswire.com/Resource/Download/b85bbdee-9fda-4cf2-a14f-d2d608f0b949?size=2" nborder="0" align="left" hspace="5" vspace="5" title="Rivus Pharmaceuticals Logo.png" alt="Rivus Pharmaceuticals, Inc."/>- Preclinical NHP data demonstrate significant fat‑specific weight loss with RV‑8451, while preserving lean mass and showing no gastrointestinal adverse events - - IND‑enabling studies advancing, with IND submission for RV-8451 in obesity targeted for Q1 2027 - - Greater fat loss in head-to-head NHP study versus orforglipron while preserving lean mass - CHARLOTTESVILLE, Va., and SOUTH SAN FRANCISCO, Calif., June 05, 2026 (GLOBE NEWSWIRE) -- Rivus Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company focused on advancing cardiometabolic health, today announced preclinical data for RV-8451, a novel, muscle-preserving, oral GLP-1 receptor agonist (GLP-1RA) in development for the treatment of obesity. The data in diet-induced obese (DIO) non-human primates (NHPs) are being featured in an oral presentation today at 2:45 p.m. CT at the American Diabetes Association’s (ADA) 86th Scientific Sessions, taking place June 5-8, 2026 in New Orleans, LA. “We are excited to present preclinical obesity data for RV-8451, demonstrating the potential of our highly-differentiated, oral GLP-1 to deliver quality, muscle-preserving weight loss,” said Shaharyar Khan, Ph.D., Chief Scientific Officer of Rivus Pharmaceuticals. “In two independent studies in obese NHPs, RV-8451 produced robust, fat-selective weight loss while preserving lean mass. We are particularly encouraged by a head-to-head study versus orforglipron, showing RV-8451 resulted in similar weight loss with greater fat loss while preserving lean mass. These data reinforce the potential of RV-8451 as a novel, muscle-preserving, oral GLP-1 and provide a strong foundation as we advance our second oral medicine toward a planned IND submission in obesity in the first quarter of 2027.” Oral Presentation: RV-8451 Preclinical Obesity Data in NHPs RV-8451 Monotherapy: Results from a preclinical model of DIO NHPs treated with RV-8451 for 18 days following a 7-day vehicle acclimatation period showed: <ul type="disc"><li>Energy Intake: 53% reduction in daily food intake (p&lt;0.05 from baseline)</li><li>Weight Loss: 9% reduction in body weight (p&lt;0.05 from baseline)</li><li>Fat Loss: Up to 20% reduction in fat mass (p&lt;0.05 from baseline)</li><li>Lean Mass Preservation: No change in lean mass, as measured by DEXA</li><li>Additional Cardiometabolic Measures: Improved clinical chemistry, with reductions in plasma alanine transaminase (ALT), triglycerides, and total cholesterol</li><li>Safety and Tolerability: No drug-related gastrointestinal adverse events observed </li></ul> RV-8451 versus Orforglipron: Results from a preclinical model of DIO NHPs treated with RV-8451 or orforglipron for 28 days showed: <ul type="disc"><li>Weight Loss: Similar reductions in weight loss (7%)</li><li>Fat Loss: Greater fat loss with RV-8451 compared to orforglipron (30% vs. 11% reduction, p&lt;0.05)</li><li>Lean Mass Preservation: Increase in lean mass with RV-8451, compared to loss of lean mass with orforglipron (4% increase versus 6% decrease, p&lt;0.05)</li><li>Safety and Tolerability: No drug-related gastrointestinal adverse events observed for RV-8451 </li></ul> Presentation details are as follows: ADA 2026 Abstract Title: Muscle-Preserving Weight Loss With RV-8451, a Novel, Oral Non-Peptide GLP-1 Receptor Agonist, in Diet-Induced Obese Non-Human Primates Abstract Tracking Number: 2026-A-3220-Diabetes Format: Oral Presentation Presenter: Sol Collado, Ph.D., Executive Director, Drug Discovery, Rivus Pharmaceuticals Presentation Date and Time: Friday, June 5, 2026, 2:45 p.m. CT Abstract Title: Discovery of RV-8451, a Novel, Oral, Muscle-Preserving Small Molecule GLP-1 Receptor Agonist Abstract Tracking Number: 2026-A-3219-Diabetes Format: Poster Presentation Presenter: Sol Collado, Ph.D., Executive Director, Drug Discovery, Rivus Pharmaceuticals Presentation Date and Time: Monday, June 8, 2026, 12:30 - 1:30 p.m. CT Following the sessions, copies of the presentation and poster will be accessible under “Publications” in the Pipeline section of <a href="https://www.globenewswire.com/Tracker?data=kujfuH8cz7oxgJvMDwiR2gx8-mLbhKOKtvm1oJXh_gn4bsYUawI0MXKKP9rSfaMFXbW7akBW9IswkqMsJi-uXn-N5TlAFbf6v5yGrphmWkX-O7xBNewN2BOJXEAImwc9" rel="nofollow" target="_blank" title="Rivus’ website">Rivus’ website</a>. About Obesity Obesity affects more than one billion people worldwide and is a primary driver of cardiometabolic disease. While currently approved GLP-1 receptor agonists have delivered meaningful benefit, they are also associated with significant limitations, including loss of lean muscle mass (an estimated 20–40% of total weight lost), gastrointestinal tolerability issues, and high rates of discontinuation. When treatment is stopped, patients often rapidly regain weight – primarily as fat – which can leave body composition worse than when they started. RV-8451 is designed to address these limitations by producing high-quality, fat-selective, and durable weight loss while preserving muscle. About RV-8451 RV-8451 is Rivus’ highly-differentiated, oral, small molecule GLP-1 receptor agonist in preclinical development for obesity. RV-8451 is the first muscle-preserving, oral non-peptide GLP-1 agonist, designed to deliver high-quality, fat-selective, durable weight loss with convenient oral dosing. Rivus plans to submit an Investigational New Drug (IND) application to advance RV-8451 into a Phase 1 clinical trial in obesity. About Rivus Pharmaceuticals Rivus Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company focused on advancing cardiometabolic health. The company’s lead candidate, HU6, is a potential best-in-class oral therapeutic to treat MASH currently advancing in the Phase 2 AMPLIFY trial. Rivus is also advancing RV-8451, the first muscle-preserving, oral GLP-1, in preclinical development to treat obesity. Rivus’ proprietary platform is focused on developing oral medicines that incorporate energy expenditure to deliver improved and sustained cardiometabolic health. Follow Rivus on <a href="https://www.globenewswire.com/Tracker?data=g0O9shDC1FpnepF6fmYV1iSQKZJVgivisGg2-0q-FcisMi5uzW69AjnktdGO4TfjnQng7DRgjKC7ZwWZFBoTdbsQvskbmLg5cQx1vB_wHCyYsNf-7L5lt-a9strMoLjxdO1qUcxy9SjxDBo77Rmgsw==" rel="nofollow" target="_blank" title="LinkedIn">LinkedIn</a> and <a href="https://www.globenewswire.com/Tracker?data=b0smaWJpVZwf78s4fMebGw2EJZt92hNbNDHFr6o8BUYNOuAT3HghhAS4FGJ5J6FG52srsWqqIbJAiRKUoB8CXw==" rel="nofollow" target="_blank" title="X">X</a> and visit <a href="https://www.globenewswire.com/Tracker?data=ficmstOsVJQdZ7jGZC-W0bleJhpb7SMXobD2VcoIKvxloU2dOqiudF9O8rhyZNAmxfeWqzo_QU73-8GDjNtZ4A29g_-1gIGJMLAWPrjbc5U=" rel="nofollow" target="_blank" title="www.rivuspharma.com">www.rivuspharma.com</a>. 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Rivus Pharmaceuticals Announces Preclinical Data for RV-8451, a Muscle-Preserving, Oral GLP-1, at ADA 2026 Scientific Sessions

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