<img src="https://ml.globenewswire.com/Resource/Download/e2f985bf-0880-4d05-8838-90a69c888cf9?size=2" nborder="0" align="left" hspace="5" vspace="5" title="Logo.jpg" alt="Scilex Holding Company"/>PALO ALTO, Calif., May 22, 2026 (GLOBE NEWSWIRE) -- Scilex Holding Company (“Scilex” or the “Company”) (Nasdaq: SCLX), an innovative revenue-generating company focused on acquiring, developing, and commercializing non-opioid pain management products for the treatment of acute and chronic pain and neurodegenerative and cardiometabolic disease, today announced that its board of directors (the “Board”) approved a dividend of Semnur Pharmaceuticals, Inc. (“Semnur”) (OTC: SMNR) common stock held by the Company to its stockholders and certain other eligible equityholders of Scilex (collectively, the “Participating Holders”). The record date for the dividend is June 1, 2026 (the “Record Date”). The Participating Holders as of the Record Date will be entitled to receive one (1) share of common stock of Semnur for each share of Scilex common stock held (or for each share of common stock issuable or deemed issuable upon exercise or conversion of such other eligible securities). Scilex currently holds approximately 186 million shares of Semnur common stock and plans to distribute approximately 10.7 million of such shares to the Participating Holders based on the foregoing ratio. The Record Date for the dividend may be changed by the Board for any reason at any time prior to the actual payment date, and payment of the dividend is conditioned upon the Board having not revoked the dividend prior to the payment date, including for a material change to the solvency or surplus analysis presented to the Board. Subject to the right of the Board to change the Record Date, the payment date for the dividend will be determined by subsequent resolutions of the Board, which payment date will be within 60 days following the Record Date (the “Payment Date”). For more information on Scilex Holding Company, refer to <a href="https://www.globenewswire.com/Tracker?data=jaVK-lkDgNGLlqRoaXBBzPlp1F-lskDiF4UbxfPaj8i74eViVogGPfcBqq1KbXzeNkmsPz0_49RaD1jLplUTONMomFkz0MRYWxmaX1QfyKg=" rel="nofollow" target="_blank" title="www.scilexholding.com">www.scilexholding.com</a> For more information on Semnur Pharmaceuticals, Inc., refer to <a href="https://www.globenewswire.com/Tracker?data=jaVK-lkDgNGLlqRoaXBBzFLvyuNNDMX1pd8M-W2rSAShJ61N1Fl85-Hy786VOi7vja-XPjcFDdpQm4VmlxVAT8R7ulZLR0YQMDQcL8Z2h0c=" rel="nofollow" target="_blank" title="www.semnurpharma.com">www.semnurpharma.com</a> For more information on ZTlido® including Full Prescribing Information, refer to <a href="https://www.globenewswire.com/Tracker?data=Yd_TcwGCm81lRQRDN7ofEBLoIBM7tGKwluAphNTr3JrExm_a3GYMx0Ea8kVRK0a6bwIIAOk_AQHD1bo1gUSigQ==" rel="nofollow" target="_blank" title="www.ztlido.com">www.ztlido.com</a>. For more information on ELYXYB®, including Full Prescribing Information, refer to <a href="https://www.globenewswire.com/Tracker?data=mCvTbXuV7QezxS0bkaGVj5mCMXupG9EJT671OmtaXwtC-hW01fKmjpcuXugr7Th1V-BWVRId3N0aIVPZIzyeIQ==" rel="nofollow" target="_blank" title="www.elyxyb.com">www.elyxyb.com</a>. For more information on Gloperba®, including Full Prescribing Information, refer to <a href="https://www.globenewswire.com/Tracker?data=JQVH9X9vZ_80tkWEajOII5iL3pJQnnX-JaIUAXDz8zmOgtO7l7Kmo9MHHREKQd2g3ghjObZL-UNg7JJPhhu5QNrGXs6WtUMf5NEQL2Y7PoI=" rel="nofollow" target="_blank" title="www.gloperba.com">www.gloperba.com</a>. <a href="https://www.globenewswire.com/Tracker?data=HOpm8GGEm6XQ8VJyTKqgC20ZnEJLENFgkuWXWQ5XNK7sZI4fjuFweR--s0mT-US5cd4Rc8xAEjja4FXxsFEXTSOuIRuHXNOPaumuKMGNXHOufpCGghMC_5NPGMWYW0KjsOKPcDMI1NfZHvJ_O_UliA==" rel="nofollow" target="_blank" title="">https://www.facebook.com/scilex.pharm</a> <a href="https://www.globenewswire.com/Tracker?data=HOpm8GGEm6XQ8VJyTKqgC29_t5TRFce-6H_LVMezg73qemHf1NSKIxtp3ANp-jy70zi6vRi10GeGLFxyoIYOUdNC2IrzWsc7yPFY8TgGF5Qc3dDf-lFSItfTUFa6iMf4L-coNSSxNXjM_2HynvPhyE2wJ4W05X1_pqG7sbgS_nWefxlHa_WB-45tOnzvXWMG" rel="nofollow" target="_blank" title="">https://www.linkedin.com/company/scilex-holding-company/</a> <a href="https://www.globenewswire.com/Tracker?data=QND9oVeLsI75npqQ1V3gYRmsRMxhcwhg0dKregznuKWbSihC-oIHGKNeNXEYu814snnRzFdKMzel2_XPU3UGzc6nHZBYprA9yeqsC6NeyNA=" rel="nofollow" target="_blank" title="info@scilexholding.com">info@scilexholding.com</a>  About Scilex Holding Company Scilex is an innovative revenue-generating company focused on acquiring, developing and commercializing non-opioid pain management products for the treatment of acute and chronic pain and neurodegenerative and cardiometabolic disease. Scilex targets indications with high unmet needs and large market opportunities with non-opioid therapies for the treatment of patients with acute and chronic pain and is dedicated to advancing and improving patient outcomes. Scilex’s commercial products include: (i) ZTlido® (lidocaine topical system) 1.8%, a prescription lidocaine topical product approved by the U.S. Food and Drug Administration (the “FDA”) for the relief of neuropathic pain associated with postherpetic neuralgia, which is a form of post-shingles nerve pain; (ii) ELYXYB®, a potential first-line treatment and the only FDA-approved, ready-to-use oral solution for the acute treatment of migraine, with or without aura, in adults; and (iii) Gloperba®, the first and only liquid oral version of the anti-gout medicine colchicine indicated for the prophylaxis of painful gout flares in adults. In addition, Scilex has three product candidates: (i) SP-102 (10 mg, dexamethasone sodium phosphate viscous gel) (“SEMDEXA” or “SP-102”), which is owned by Semnur (a majority owned subsidiary of Scilex) and is a novel, viscous gel formulation of a widely used corticosteroid for epidural injections to treat lumbosacral radicular pain, or sciatica, for which Scilex has completed a Phase 3 study and was granted Fast Track status from the FDA in 2017; (ii) SP-103 (lidocaine topical system) 5.4%, (“SP-103”), a next-generation, triple-strength formulation of ZTlido, for the treatment of acute pain and for which Scilex has recently completed a Phase 2 trial in acute low back pain. SP-103 has been granted Fast Track status from the FDA in low back pain; and (iii) SP-104 (4.5 mg, low-dose naltrexone hydrochloride delayed-release capsules) (“SP-104”), a novel low-dose delayed-release naltrexone hydrochloride being developed for the treatment of fibromyalgia. Scilex is headquartered in Palo Alto, California. About Semnur Pharmaceuticals, Inc. Semnur is a clinical late-stage specialty pharmaceutical company focused on the development and commercialization of novel non-opioid pain therapies. Semnur’s product candidate, SP-102 (SEMDEXA™), is the first non-opioid novel gel formulation administered epidurally in development for patients with moderate to severe chronic radicular pain/sciatica. Semnur is headquartered in Palo Alto, California Forward-Looking Statements This press release includes forward-looking statements that involve risks and uncertainties. Forward-looking statements are statements that are not historical facts and may be accompanied by words that convey projected future events or outcomes, such as “believe,” “may,” “will,” “estimate,” “continue,” “anticipate,” “intend,” “expect,” “should,” “would,” “plan,” “predict,” “potential,” “seem,” “seek,” “future,” “outlook” or variations of such words or by expressions of similar meaning. These forward-looking statements include, but are not limited to, statements regarding future events, including Scilex’s dividend of Semnur common stock and the timing thereof (including that the Payment Date will be determined by subsequent resolutions of the Board, and that the Board may change the Record Date and, as a result, the Payment Date, once determined). These statements are based on management’s current expectations and are not predictions of actual performance. These forward-looking statements are provided for illustrative purposes only and are not intended to serve as, and must not be relied on, by any investor as a guarantee, an assurance, a prediction or a definitive statement of fact or probability. Actual events and circumstances are difficult or impossible to predict and will differ from assumptions. Many actual events and circumstances are beyond the control of Scilex. These statements are subject to a number of risks and uncertainties regarding Scilex’s business. These risks and uncertainties include, but are not limited to, risks related to legal proceedings that may be instituted against Scilex regarding the dividend of Semnur common stock and the payment thereof to the Participating Holders; risks associated with the right of the Board to change the Record Date and the Payment Date and/or revoke the dividend; general economic, political and business conditions; the ability of Scilex and its subsidiaries to develop and successfully market products; the ability of Scilex and its subsidiaries to grow and manage growth profitably and retain its key employees; the risk that the potential product candidates that Scilex develops may not progress through clinical development or receive required regulatory approvals within expected timelines or at all; risks relating to uncertainty regarding the regulatory pathway for Scilex’s product candidates; the risk that Scilex’s product candidates may not be beneficial to patients or successfully commercialized; the risk that Scilex has overestimated the size of the target patient population, their willingness to try new therapies and the willingness of physicians to prescribe these therapies; risks that the prior results of the clinical trials may not be replicated; regulatory and intellectual property risks; and other risks and uncertainties indicated from time to time and other risks set forth in Scilex’s filings with the SEC. There may be additional risks that Scilex presently does not know or that Scilex currently believes are immaterial that could also cause actual results to differ from those contained in the forward-looking statements. In addition, forward-looking statements provide Scilex’s expectations, plans or forecasts of future events and views as of the date of the communication. Scilex anticipates that subsequent events and developments will cause such assessments to change. However, while Scilex may elect to update these forward-looking statements at some point in the future, Scilex specifically disclaims any obligation to do so. These forward-looking statements should not be relied upon as representing Scilex’s assessments as of any date subsequent to the date of this communication. Accordingly, investors are cautioned not to place undue reliance on these forward-looking statements. Contacts: Investors and Media Scilex Holding Company 960 San Antonio Road Palo Alto, CA 94303 Office: (650) 516-4310 Email: investorrelations@scilexholding.com Website: <a href="https://www.globenewswire.com/Tracker?data=jaVK-lkDgNGLlqRoaXBBzPlp1F-lskDiF4UbxfPaj8iuSU_-UwY5zcQFaHiKPuC6NDzucx9nZ2IofJicDeeCimZueKGqaTcscDibBr3EW9k=" rel="nofollow" target="_blank" title="www.scilexholding.com">www.scilexholding.com</a> SEMDEXA™ (SP-102) is a trademark owned by Semnur Pharmaceuticals, Inc., a majority-owned subsidiary of Scilex Holding Company. A proprietary name review by the FDA is planned. ZTlido® is a registered trademark owned by Scilex Pharmaceuticals Inc., a wholly-owned subsidiary of Scilex Holding Company. Gloperba® is the subject of an exclusive, transferable license to use the registered trademark by Scilex Holding Company. ELYXYB® is a registered trademark owned by Scilex Holding Company. Scilex Bio™ is a trademark owned by Scilex Holding Company. All other trademarks are the property of their respective owners. © 2026 Scilex Holding Company All Rights Reserved. <img alt="" src='https://ml.globenewswire.com/media/YTliMGNjZjQtODZjNS00MzU2LWFhYWUtZTBiOTc1NDgyNzc3LTEyNjYyNzYtMjAyNi0wNS0yMi1lbg==/tiny/Scilex-Holding-Company.png' referrerpolicy='no-referrer-when-downgrade' />

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Scilex Holding Company (“Scilex”) Announces Its Board of Directors Approved a Dividend of Semnur Pharmaceuticals, Inc. Common Stock to Holders of Scilex Common Stock and other Eligible Equity Securities with a Record Date of June 1, 2026

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